Grupo de Biotecnologia Molecular e Estrutural 

BARROSO-NETO, ITO L. ; DELATORRE, Plinio ; TEIXEIRA, CLAUDENER S. ; CORREIA, JORGE L.A. ; CAJAZEIRAS, João B. ; PEREIRA, RONNIERY I. ; NASCIMENTO, Kyria S. ; LARANJEIRA, EVA P.P. ; PIRES, ALANA F. ; ASSREUY, A. M. S. ; ROCHA, Bruno Anderson Matias da ; CAVADA, Benildo S. . Structural analysis of a Dioclea sclerocarpa lectin: Study on the vasorelaxant properties of Dioclea lectins. International Journal of Biological Macromolecules, v. 82, p. 464-470, 2016.

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DE FREITAS, CLEVERSON D. T. ; DA CRUZ, WALLACE T. ; SILVA, MARIA Z. R. ; VASCONCELOS, ILKA M. ; Moreno, Frederico B. M. B. ; MOREIRA, RENATO A. ; MONTEIRO-MOREIRA, ANA C. O. ; ALENCAR, LUCIANA M. R. ; SOUSA, JEANLEX S. ; Rocha, Bruno A. M. ; RAMOS, MÁRCIO V. . Proteomic analysis and purification of an unusual germin-like protein with proteolytic activity in the latex of Thevetia peruviana. Planta (Heidelberg, v. XX, p. XX, 2016.

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ALMEIDA, ALYSSON CHAVES ; OSTERNE, VINICIUS JOSE DA SILVA ; SANTIAGO, MAYARA QUEIROZ ; PINTO-JUNIOR, VANIR REIS ; SILVA-FILHO, JOSE CAETANO ; LOSSIO, CLAUDIA FIGUEIREDO ; NASCIMENTO, FRANCISCO LUCAS FAUSTINO ; ALMEIDA, RICARDO PATRICIO HONORATO ; TEIXEIRA, CLAUDENER SOUZA ; Leal, Rodrigo Bainy ; Delatorre, Plinio ; Rocha, Bruno Anderson Matias ; ASSREUY, Ana Maria Sampaio ; Nascimento, Kyria Santiago ; CAVADA, Benildo Sousa . Structural analysis of Centrolobium tomentosum seed lectin with inflammatory activity. Archives of Biochemistry and Biophysics (Print), v. 596, p. 73-83, 2016.

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ROCHA, Bruno Anderson Matias da; TEIXEIRA, CLAUDENER S. ; SILVA-FILHO, JOSÉ C. ; NÓBREGA, RAPHAEL B. ; ALENCAR, DANIEL B. ; Nascimento, Kyria S. ; Freire, Valder N. ; GOTTFRIED, CARMEM J.S. ; Nagano, Celso S. ; SAMPAIO, A.H. ; SAKER-SAMPAIO, Silvana ; Cavada, Benildo S. ; Delatorre, Plínio . Structural basis of ConM binding with resveratrol, an anti-inflammatory and antioxidant polyphenol. International Journal of Biological Macromolecules, v. 72, p. 1136-1142, 2015.

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Rocha, Bruno A.M.; BARROSO-NETO, ITO L. ; TEIXEIRA, CLAUDENER S. ; SANTIAGO, MAYARA Q. ; Pires, Alana F. ; SOUZA, LUIZ A.G. ; Nascimento, Kyria S. ; SAMPAIO, Alexandre H. ; Delatorre, Plinio ; ASSREUY, ANA M.S. ; CAVADA, Benildo S. . CRLI induces vascular smooth muscle relaxation and suggests a dual mechanism of eNOS activation by legume lectins via muscarinic receptors and shear stress. Archives of Biochemistry and Biophysics (Print), v. 565, p. 32-39, 2015.

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CARNEIRO, RÔMULO FARIAS ; TEIXEIRA, CLAUDENER SOUZA ; MELO, ARTHUR ALVES DE ; ALMEIDA, ALEXANDRA SAMPAIO DE ; CAVADA, Benildo Sousa ; SOUSA, OSCARINA VIANA DE ; ROCHA, Bruno Anderson Matias da ; Nagano, Celso Shiniti ; Sampaio, Alexandre Holanda . L-rhamnose-binding lectin from eggs of the Echinometra lucunter: amino acid sequence and molecular modeling. International Journal of Biological Macromolecules, v. 78, p. 180-188, 2015.

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SOUSA, BRUNO LOPES ; SILVA FILHO, JOSÉ CAETANO ; KUMAR, PRASHANT ; PEREIRA, RONNIERY ILÁRIO ; 'YSKOWSKI, ANDRZEJ ; ROCHA, Bruno Anderson Matias da ;Delatorre, Plínio ; BEZERRA, Gustavo Arruda ; Nagano, Celso Shiniti ; Gruber, Karl ; Cavada, B.S. . High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins. International Journal of Biochemistry & Cell Biology, v. 59, p. 103-110, 2015.

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PONTE, L. F. A. ; CARVALHO, F. E. L. ; SILVA, A. L. C. ; MAIA, J. M. ; VOIGT, E. L. ; SILVEIRA, J. A. G. . Salt-induced delay in cotyledonary globulin mobilization is abolished by induction of proteases and leaf growth sink strength at late seedling establishment in cashew (Anacardium occidentale L.). Journal of Plant Physiology (Print), v. 1, p. 1, 2014.

 

MONTENEGRO, M. A. ; Martins, J.L. ; VASCONCELOS, M. A. ; TEIXEIRA, E. H. ; SILVA, A. L. C. ; CAVADA, B. S. ; Santos, R.P. . Effect of cashew (Anacardium occidentale L.) peduncle bagasse extract on Streptococcus mutans and its biofilm. Revista Brasileira de Biociências (Impresso), v. 12, p. 1, 2014.

 

SILVA, H. C.; PINTO, L. S.; NASCIMENTO, K. S.; CAVADA, B. S.; SILVA, A. L. C. BUL: a novel lectin from Bauhinia ungulata L. seeds with fungistatic and antiproliferative activities. Process Biochemistry , 2013.

 

KLAFKE, G.; BORSUK, S.; GONCALES, R.; ARRUDA, F. V. S.; CARNEIRO, V. A.; Teixeira, Edson H.; SILVA, A. L. C.; DELLAGOSTIN, O. ; Cavada, Benildo S.; PINTO, L. S.. Inhibition of initial adhesion of oral bacteria through a lectin from Bauhinia variegata L. var. variegata expressed in Escherichia coli. Journal of Applied Microbiology (Print), v. 3, p. n/a-n/a, 2013.

 

NASCIMENTO, A. S. F. ; GONDIM, A. C. S. ; CAJASEIRAS, J. B.; CORREIA, J. L. A.; PIRES, A. F.; NASCIMENTO, K. S.; SILVA, A. L. C.; NAGANO, C. S.; ASSREUY, A. M.; CAVADA, B. S. Purification and partial characterization of a novel lectin from Dioclea lasiocarpa Martseeds with vasodilator effects. JMR. Journal of Molecular Recognition, 2012

 

NASCIMENTO, A. S. F. ; CORREIA, J. L. A.; CAJASEIRAS, J. B.; SILVA, A. L. C.; GARCIA, W. ; NASCIMENTO, K. S. ; ROCHA, B. A. M. ; SAMPAIO, A.H. ; NAGANO, C. S. ; CAVADA, B. S. . Molecular Characterization and Tandem Mass Spectrometry of the Lectin Extracted from the Seeds of Dioclea sclerocarpa Ducke. Molecules (Basel. Online), v. 16, p. 9077, 2011.

 

Nascimento, Antonia Samia F. ; Cajazeiras, Jo o B. ; Nascimento, Kyria S. ; Nogueira, Sara Monalisa S. ; Sousa, Bruno L. ; Teixeira, Edson H. ; Melo, Luciana M. ; da Cunha, Rodrigo Maranguape S. ; Silva, Andr Luiz C. ; Cavada, Benildo S. . Expression, purification and structural analysis of recombinant rBdh-2His , a spermadhesin from buck ( ) seminal plasma. Reproduction, Fertility and Development, v. X, p. XX, 2010.

 

Fabia M.B. Da Silva ;  Renato A. Moreira ; Ana C.G. Horta ; SILVA, A. L. C. The Lectin Content of Cotyledonary Callus from Canavalia brasiliensis (Mart. ex. Benth). Asian Journal of Plant Sciences, v. 4, n.3, p. 214-219, 2005.

 

SILVA, A. L. C. ; Goto, Leandro S. ; Dinarte, Anemari R. ; Hansen, Daiane ; Moreira, Renato A. ; Beltramini, Leila M. ; Araujo, Ana P. U. . Pulchellin, a highly toxic type 2 ribosome-inactivating protein from Abrus pulchellus. Cloning, heterologous expression of A-chain and structural studies. The FEBS Journal (Print), v. 272, p. 1201-1210, 2005.

 

SILVA, A. L. C.; Caruso, Cecília Sulzbacher ; MOREIRA, RENATO DE AZEVEDO ; HORTA, ANA CECÍLIA GÓES . Growth characteristics and dynamics of protein synthesis in callus cultures from Glycine wightii (Wight & Arn.) Verdc.. Ciência e Agrotecnologia, Lavras, v. 29, n.6, p. 1161-1166, 2005.

 

Silva, A . Production of Abrus pulchellus ribosome-inactivating protein from seeds callus culture. Toxicon (Oxford), v. 41, n.7, p. 841-849, 2003. 

 

SILVA, ANDRÉ LUIS COELHO DA ; Caruso, Cecília Sulzbacher ; MOREIRA, RENATO DE AZEVEDO ; HORTA, ANA CECÍLIA GÓES . In vitro induction of callus from cotyledon and hypocotyl explants of Glycine wightii (Wight & Arn.) Verdc.. Ciência e Agrotecnologia (UFLA), v. 27, p. 1277-1284, 2003.

SILVA, A. L. C. ; ARAUJO, A. P. U. Production of a ribosome-inactivating protein from callus culture of Abrus pulchellus. Preliminary studies.. Journal of Venomous Animals and Toxins Including Tropical Diseases (Online), v. 9, p. 1, 2003.

 

SILVA, ANDRÉ LUIS COELHO DA ; HORTA, ANA CECÍLIA GÓES ; MOREIRA, RENATO DE AZEVEDO . Isolation and partial characterization of a lectin from Bauhinia pentandra(Bong) vog. Ex. Steua.. Revista Brasileira de Fisiologia Vegetal (Impresso) (Cessou em 2001. Cont. ISSN 1677-0420 Brazilian Journal of Plant Physiology (Impresso), v. 13, n.3, p. 1, 2001.

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Barroso-Neto, Ito Liberato ; Simões, Rafael Conceição ; ROCHA, Bruno Anderson Matias da ; Bezerra, Maria Julia Barbosa ; Pereira-Junior, Francisco Nascimento ; SILVA OSTERNE, VINICIUS JOSÉ ; NASCIMENTO, Kyria Santiago ; NASCIMENTO, Kyria Santiago ; NAGANO, Celso Shiniti ; Delatorre, Plinio ; PEREIRA, MARIA GONÇALVES ; Freitas Pires, Alana; SAMPAIO, Alexandre Holanda ; ASSREUY, Ana Maria Sampaio ; CAVADA, Benildo Sousa . Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis. Archives of Biochemistry and Biophysics (Print), v. 543, p. 31-39, 2014.

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TEIXEIRA, CLAUDENER SOUZA ; ASSREUY, Ana Maria Sampaio ; DA SILVA OSTERNE, VINÍCIUS JOSÉ ; AMORIM, RENATA MORAIS FERREIRA ; BRIZENO, LUIZ ANDRÉ CAVALCANTE ; DEBRAY, Henri ; Nagano, Celso Shiniti ; Delatorre, Plinio ; SAMPAIO, Alexandre Holanda ; Rocha, Bruno Anderson Matias ; CAVADA, Benildo Sousa . Mannose-specific legume lectin from the seeds of Dolichos lablab (FRIL) stimulates inflammatory and hypernociceptive processes in mice. Process Biochemistry (1991), v. 49, p. 529-534, 2014.

BEZERRA, Gustavo Arruda ; VIERTLMAYR, ROLAND ; Moura, Tales Rocha ; DELATORRE, Plínio ; Rocha, Bruno Anderson Matias ; do Nascimento, Kyria Santiago ; FIGUEIREDO, JOZI GODOY ; BEZERRA, INGRID GONÇALVES ; TEIXEIRA, CICERO SILVANO ; SIMÕES, RAFAEL CONCEIÇÃO ; Nagano, Celso Shiniti ; DE ALENCAR, NYLANE MARIA NUNES ; Gruber, Karl ; CAVADA, Benildo Sousa . Structural Studies of an Anti-Inflammatory Lectin from Canavalia boliviana Seeds in Complex with Dimannosides. Plos One, v. 9, p. e97015, 2014

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OSTERNE, VINICIUS J. S. ; SANTIAGO, MAYARA Q. ; PINTO-JUNIOR, VANIR R. ; Cajazeiras, João B. ; CORREIA, JORGE L. A. ; LEITÃO, CINTIA C. F. ; CARNEIRO, RÔMULO F. ; PEREIRA-JUNIOR, FRANCISCO N. ; VASCONCELOS, MAYRON A. ; ROCHA, Bruno Anderson Matias da ; Assreuy, Ana Maria S. ; BRINGEL, PEDRO HENRIQUE S. F. ; Nagano, Celso S.; Nascimento, Kyria S. ; Cavada, B.S. . Purification, Partial Characterization, and CNBr-Sepharose Immobilization of a Vasorelaxant Glucose/Mannose Lectin from Canavalia virosa Seeds. Applied Biochemistry and Biotechnology, v. 172, p. 3342-3353, 2014.

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BEZERRA, Maria Julia Barbosa ; RODRIGUES, N. V. F. C. ; PIRES, A. F. ; BEZERRA, Gustavo A ; Nobre, C.B. ; ALENCAR, K. L. L. ; SOARES, P. M. G. ; NASCIMENTO, Kyria S ;NAGANO, Celso S ; MARTINS, Jorge L ; GRUBER, K. ; SAMPAIO, Alexander H ; Delatorre, Plinio ; Rocha, Bruno AM ; ASSREUY, Ana Maria Sampaio ; CAVADA, Benildo S. . Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin. International Journal of Biochemistry & Cell Biology, v. 45, p. 807-815, 2013.

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Delatorre, Plinio ; SILVA-FILHO, JOSÉ CAETANO ; Rocha, Bruno Anderson Matias ; SANTI-GADELHA, Tatiane ; DA NÓBREGA, RAPHAEL BATISTA ; GADELHA, CARLOS ALBERTO ALMEIDA ; do Nascimento, Kyria Santiago ; Nagano, Celso Shiniti ; Sampaio, Alexandre Holanda ; CAVADA, Benildo Sousa . Interactions between indole-3-acetic acid (IAA) with a lectin from Canavalia maritima seeds reveal a new function for lectins in plant physiology. Biochimie (Paris. Print), v. 95, p. 1697-1703, 2013.

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BARI, ALFA U. ; SILVA, HELTON C. ; SILVA, MAYARA T. L. ; PEREIRA JÚNIOR, FRANCISCO N. ; CAJAZEIRAS, JOÃO B. ; Sampaio, Alexandre H. ; SAMPAIO, A.H. ; LEAL, RODRIGO B. ; Teixeira, Edson H. ; ROCHA, Bruno Anderson Matias da ; Nascimento, Kyria S. ; Nagano, Celso S. ; Cavada, Benildo S. . Purification and partial characterization of a new mannose/glucose-specific lectin from Dialium guineense Willd seeds that exhibits toxic effect. JMR. Journal of Molecular Recognition, v. 26, p. 351-356, 2013.

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SILVA, HELTON C. ; BARI, ALFA U. ; ROCHA, BRUNO ANDERSON M. ; Nascimento, Kyria S. ; PONTE, EDSON L. ; Pires, Alana F. ; DELATORRE, Plínio ; Teixeira, Edson H. ; DEBRAY, Henri ; Assreuy, Ana Maria S. ; Nagano, Celso S. ; CAVADA, Benildo S. . Purification and primary structure of a mannose/glucose-binding lectin from Parkia biglobosa Jacq. seeds with antinociceptive and anti-inflammatory properties. JMR. Journal of Molecular Recognition, v. 26, p. 470-478, 2013.

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ARAÚJO, THEOLYTA S. ; TEIXEIRA, CLAUDENER S. ; FALCÃO, MARIA A. P. ; JUNIOR, VANIR R. PINTO ; SANTIAGO, MAYARA QUIROZ ; Benevides, Raquel G. ; DELATORRE, Plínio; MARTINS, JORGE L. ; ALEXANDRE-MOREIRA, MAGNA S. ; CAVADA, Benildo S. ; CAMPESATTO, ELIANE A. ; Rocha, Bruno A. M. . Anti-inflammatory and Antinociceptive Activity of Chitin-binding Lectin from Canna Limbata Seeds. Applied Biochemistry and Biotechnology, v. 171, p. 1944-1955, 2013.

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CARNEIRO, RÔMULO FARIAS ; DE MELO, ARTHUR ALVES ; NASCIMENTO, FERNANDO EDSON PESSOA DO ; SIMPLICIO, CLAREANE AVELINO ; Nascimento, Kyria Santiago do ;ROCHA, Bruno Anderson Matias da ; SAKER-SAMPAIO, SILVANA ; MOURA, RANIERE DA MATA ; MOTA, SULA SALANI ; CAVADA, Benildo Sousa ; Nagano, Celso Shiniti ; SAMPAIO, Alexandre Holanda . Halilectin 1 (H-1) and Halilectin 2 (H-2): two new lectins isolated from the marine sponge Haliclona caerulea. JMR. Journal of Molecular Recognition, v. 26, p. 51-58, 2013.

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ABRANTES, VANESSA ERIKA FERREIRA ; Rocha, Bruno AM ; NOBREGA, R. B. ; SILVA-FILHO, JOSÉ CAETANO ; Teixeira, C.S. ; CAVADA, Benildo S. ; GADELHA, Carlos Alberto de Almeida ; FERREIRA, SERGIO HENRIQUE ; FIGUEIREDO, JOZI GODOY ; SANTI-GADELHA, Tatiane ; Delatorre, Plinio . Molecular Modeling of Lectin-Like Protein from Acacia farnesiana Reveals a Possible Anti-Inflammatory Mechanism in Carrageenan-Induced Inflammation. BIOMED RES INT, v. 2013, p. 1-9, 2013.

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Simões, Rafael Conceição ; Rocha, Bruno Anderson Matias ; BEZERRA, Maria Julia Barbosa ; Barroso-Neto, Ito Liberato ; Pereira-Junior, Francisco Nascimento ; Mata Moura, Raniere ; Nascimento, Kyria Santiago do ; Nagano, Celso Shiniti ; Delatorre, Plinio ; Freitas Pires, Alana ; ASSREUY, Ana Maria Sampaio ; Sampaio, Alexandre Holanda ; CAVADA, Benildo Sousa . Protein crystal content analysis by mass spectrometry and preliminary X-ray diffraction of a lectin from Canavalia grandiflora seeds with modulatory role in inflammation. RCM. Rapid Communications in Mass Spectrometry, v. 26, p. 811-818, 2012.

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Rangel, Thaiz Batista Azevedo ; Rocha, Bruno Anderson Matias ; BEZERRA, Gustavo Arruda ; ASSREUY, Ana Maria Sampaio ; Pires, Alana de Freitas ; do Nascimento, Antonia Sâmia Fernandes ; BEZERRA, Maria Julia Barbosa ; do Nascimento, Kyria Santiago ; Nagano, Celso Shiniti ; Sampaio, Alexandre Holanda ; Gruber, Karl ; DELATORRE, Plínio ; Fernandes, Patrícia Machado Bueno ; CAVADA, Benildo Sousa . Crystal structure of a pro-inflammatory lectin from the seeds of Dioclea wilsonii Standl. Biochimie (Paris. Print), v. 94, p. 525-532, 2012.

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Batista da Nóbrega, Raphael ; Rocha, Bruno A.M. ; Gadelha, Carlos Alberto A. ; SANTI-GADELHA, Tatiane ; Pires, Alana F. ; Assreuy, Ana Maria S. ; Nascimento, Kyria S. ; Nagano, Celso S. ; SAMPAIO, Alexandre H. ; CAVADA, Benildo S. ; Delatorre, Plinio . Structure of Dioclea virgata lectin: Relations between carbohydrate binding site and nitric oxide production. Biochimie (Paris. Print), v. 94, p. 900-906, 2012.

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de Vasconcelos, Mayron Alves ; Cunha, Claudio Oliveira ; Arruda, Francisco Vassiliepe Sousa ; Carneiro, Victor Alves ; Mercante, Fabio Martins ; do Nascimento Neto, Luiz Gonzaga ; de Sousa, Giselly Soares ; Rocha, Bruno Anderson Matias ; Teixeira, Edson Holanda ; CAVADA, Benildo Sousa ; dos Santos, Ricardo Pires . Lectin from Canavalia brasiliensis Seeds (ConBr) Is a Valuable Biotechnological Tool to Stimulate the Growth of Rhizobium tropici in Vitro. Molecules (Basel. Online), v. 17, p. 5244-5254, 2012.

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Pereira-Junior, Francisco Nascimento ; Silva, Helton Colares ; Freitas, Beatriz Tupinambá ; ROCHA, Bruno Anderson Matias da ; Nascimento, Kyria Santiago ; Nagano, Celso Shinitti ; Leal, Rodrigo Bainy ; SAMPAIO, Alexandre Holanda ; Cavada, Benildo Sousa ; Cavada, B.S. . Purification and characterization of a mannose/N-acetyl- d-glucosamine-specific lectin from the seeds of Platymiscium floribundum Vogel. JMR. Journal of Molecular Recognition, v. 25, p. 443-449, 2012.

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Santi-Gadelha, T. ; Rocha, B.A.M. ; Gadelha, C.A.A. ; Silva, H.C. ; Castellon, R.E.R. ; GONÇALVES, F.J.T. ; Toyama, D.O. ; Toyama, M.H. ; de Souza, A.J.F. ; Beriam, L.O.S. ;Martins, J.L. ; Joazeiro, P.P. ; Cavada, B.S. . Effects of a lectin-like protein isolated from Acacia farnesiana seeds on phytopathogenic bacterial strains and root-knot nematode. Pesticide Biochemistry and Physiology, v. 103, p. 15-22, 2012.

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SILVA, HELTON C. ; Nagano, Celso S. ; Souza, Luis A.G. ; Nascimento, Kyria S. ; ISÍDRO, RENATO ; DELATORRE, Plínio ; ROCHA, BRUNO ANDERSON M. ; SAMPAIO, Alexandre H. ; Assreuy, Ana Maria S. ; Pires, Alana F. ; DAMASCENO, LUIS EDUARDO A. ; MARQUES-DOMINGOS, GABRIELA F.O. ; CAVADA, Benildo S. . Purification and primary structure determination of a galactose-specific lectin from Vatairea guianensis Aublet seeds that exhibits vasorelaxant effect. Process Biochemistry (1991), v. 47, p. 2347-2355, 2012.

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SOUZA TEIXEIRA, C. ; COLARES DA SILVA, H. ; ROCHA DE MOURA, T. ; Pereira-Junior, F. N. ; SANTIAGO DO NASCIMENTO, K. ; SHINITI NAGANO, C. ; HOLANDA SAMPAIO, A.; Delatorre, P. ; MATIAS ROCHA, B. A. ; SOUSA CAVADA, B. . Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite. Journal of Biochemistry (Tokyo), v. 152, p. 87-98, 2012